PDL1 expression is a poor-prognosis factor in soft-tissue sarcomas
نویسندگان
چکیده
منابع مشابه
GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas
OBJECTIVE Recent studies have investigated the significance of GATA3 expression in patients with various malignant tumors. However, no previous studies have evaluated the clinicopathological importance of GATA3 expression in soft tissue sarcomas (STS) patients. METHODS We evaluated GATA3 expression in 76 STS cases using immunohistochemical analysis, and statistically compared clinicopathologi...
متن کاملExpression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
UNLABELLED Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, ...
متن کاملOverexpression of cyclin D1 is associated with poor prognosis in extremity soft-tissue sarcomas.
Binding of G1 cyclins to cyclin-dependent kinases leads to phosphorylation of the retinoblastoma protein and progression through G1 and S phases of the cell cycle. Overexpression of cyclins is thought to deregulate this process and has been noted in many human malignancies. This study was conducted to assess patterns of expression and potential gene amplification of the G1 cyclins in 84 patient...
متن کاملCytoplasmic maspin expression predicts poor prognosis of patients with soft tissue sarcomas
BACKGROUND Maspin is a 42 kDa protein known to act as a tumor suppressor. Although its function has not been fully elucidated, numerous reports have investigated the prognostic impact of maspin in patients with several types of cancer. However, there have been no reports on the association between maspin expression and the prognosis of patients with soft tissue sarcomas (STS). The aim of this s...
متن کاملKi-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
Soft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent <1% of types of cancer. Despite this low frequency, the disease is aggressive and treatment, when possible, is based on traditional chemotherapies. A number of cases of resistance to adjuvant therapies have been reported. Metastases are commonly identified in STS patients during ...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2017
ISSN: 2162-402X
DOI: 10.1080/2162402x.2016.1278100